Armour-LX Lite Batting Leg Guard (White-Green)
₹1,619.00 – ₹1,679.00
The ARMOUR-LX5 is best budget-range leg guard (batting pad) constructed of 7 flat (sheet) knee layer of high-density foam reinforcement and extended foam filled side wings. Also comprises with high-density sponge filled vertical bolster with TPU insert for knee protection and design features keeping it minimal and stylish for the most passionate cricketers.
Description
The ARMOUR-LX Lite is best budget-range leg guard (batting pad) with light weight (EVA foam shell) on top having moulded construction with compact wrap around fit both sides. Also comprises with low-density foam filled vertical bolster with unique separate knee and side protection split into butterfly style having design features minimal and stylish for the most passionate cricketers.
- ARMOUR-LX Lite is best budget-range batting leg guard (batting pad)
- Light weight (EVA foam shell) on top having moulded construction with compact wrap around
- Low-density foam filled vertical bolster with unique separate knee and side protection split
- Ambidextrous, can be used for both Right and Left handed batsmen
- Two Velcro straps for quick and easy use
Additional information
Color | Green, White |
---|---|
Protection Range | LX (LEG GUARD) |
Size | BOYS, MEDIUM, SMALL BOYS, YOUTH |
HAND / LEG | AMBIDEXTROUS |
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Levels of testosterone improve during puberty, when it helps boys develop muscle strength and physique hair.
For men fighting low testosterone who are attempting to conceive, a urologist may prescribe this drug to spice up testosterone ranges.
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Long-acting opioids such as methadone, morphine sulphate, fentanyl and oxycodone for the remedy of continual pain often lead to opioid-induced androgen deficiency (OPIAD).
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Over a interval of 6 months there’s a reduction in fat physique mass and a rise in lean physique mass,
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Anavar is awesome, but costly, since you have to take lots
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This dose is often adopted by individuals who’ve
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For these exploring non-steroidal choices for muscle development, YK-11 is a powerful myostatin inhibitor
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I’ve been on 60 mg break up over three instances a day for four weeks,
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Due to the stimulative results of clenbuterol, energy and motivation levels are prone to improve.
We encourage everyone to make informed decisions
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It’s beneficial to stick with the PCT for 4-6 weeks for best
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Parts like modifications in body weight, energy, and the adverse effects of using anabolic steroids are serious because looks of any adverse effects have to be
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Testicular atrophy is a common signal of decreased testosterone levels and impaired spermatogenesis.
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Nortriptyline: Uses, ipamorelin side effects study Effects,
Interactions, Pictures, Warnings & Dosing
Nortriptyline – Uses, Side Effects, and More
—
Uses
What is nortriptyline used for?
Nortriptyline is a tricyclic antidepressant (TCA) primarily prescribed to
treat major depressive disorder in adults. In addition to depression, it is often employed off‑label
for chronic neuropathic pain, fibromyalgia, migraine prophylaxis, and
certain anxiety disorders. Some clinicians also use it for insomnia when other medications are unsuitable.
How does nortriptyline work (mechanism of action)?
Nortriptyline functions by inhibiting the reuptake of norepinephrine and serotonin in the central nervous system, increasing their availability
in synaptic clefts. This modulation enhances mood regulation and pain perception pathways.
The drug also blocks several receptors—histamine H1, muscarinic acetylcholine, alpha‑adrenergic,
and some serotonin receptors—contributing to its side‑effect profile.
How is nortriptyline supplied (dosage forms)?
Nortriptyone is available in oral tablet form, typically 25 mg, 50 mg, or 100 mg.
Tablets are taken once daily, usually at bedtime, with or without food.
The medication can be crushed and mixed with a small amount of liquid for patients who have difficulty swallowing.
How should I store nortriptyline?
Keep the tablet bottle tightly closed in its original container.
Store it at room temperature away from moisture, heat, and direct
sunlight. Do not keep it in the bathroom or near
hot water heaters. Children and pets must be kept out of reach to avoid accidental ingestion.
—
Side Effects
What are the most common side effects of nortriptyline?
Dry mouth
Constipation
Drowsiness or fatigue
Blurred vision
Weight gain or increased appetite
Orthostatic hypotension (a drop in blood pressure upon standing)
These symptoms often diminish after a few weeks as the body adjusts to the medication.
What are the serious side effects of nortriptyline?
Severe dizziness leading to falls
Rapid or irregular heartbeat
Confusion, hallucinations, or severe agitation
Difficulty urinating (urinary retention)
Signs of an allergic reaction: rash, itching, swelling, especially of face
or throat
Seizures or convulsions in rare cases
If any of these occur, seek medical attention promptly.
Warnings & Precautions
Who should not use nortriptyline?
People with a history of:
Cardiac arrhythmias or heart failure
Recent heart attack
Severe liver disease
Glaucoma (particularly narrow‑angle)
Active urinary retention or severe constipation
Epilepsy (due to seizure risk)
nortriptyline is generally avoided in pregnancy
and breastfeeding unless the benefits outweigh risks.
What should I know about nortriptyone before using it?
It can interact with other CNS depressants, increasing drowsiness.
Alcohol consumption may intensify side effects
such as dizziness or impaired judgment. Patients must be monitored for signs of serotonin syndrome if combined with serotonergic agents.
What should I tell my healthcare provider before using nortriptyline?
Disclose:
All current medications (prescription, OTC, herbal supplements)
History of depression, anxiety, seizures, or heart disease
Any recent changes in liver function tests
Use of alcohol or recreational drugs
This information helps tailor dosing and monitor
for potential complications.
Interactions
Does nortriptyline interact with foods or drinks?
Alcohol can potentiate CNS depressant effects. Certain foods
high in tyramine (e.g., aged cheeses, cured meats) may not directly affect nortriptyone but should
be noted if combined with other MAO inhibitors. Generally,
no specific dietary restrictions are required.
Does nortriptyline interact with other medicines (drug interactions)?
Yes. Notable interactions include:
MAO inhibitors: risk of serotonin syndrome.
SSRIs or SNRIs: increased serotonin levels.
Beta‑blockers: additive blood pressure lowering.
CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): higher nortriptyone plasma concentrations.
Other anticholinergic drugs: exacerbate dry mouth,
constipation, blurred vision.
Always inform your prescriber of all medications to avoid harmful interactions.
Overdose/Missed Dose
What should I do if I accidentally use too much nortriptyline?
If an overdose is suspected (e.g., excessive
drowsiness, confusion, seizures), seek emergency medical help
immediately. Call local poison control or go to the nearest emergency department.
Do not induce vomiting unless instructed.
What should I do if I miss a dose of nortriptyline?
Take the missed dose as soon as remembered. If it is near
the time for your next scheduled dose, skip the missed one and
resume regular dosing. Do not double‑dose to catch up, as this
can increase side‑effect risk.
—
You Might Also Like
Are you currently using Nortriptyline?
Discuss your experience with a healthcare professional or support group.
More on Drugs & Medications
Drug Recalls: What Do They Mean?
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Is Your Medication Making You Tired?
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Anabolic Steroids: Uses, Side Effects, And Alternatives
An Overview of Anabolic Steroids – Facts, Uses, Risks and
Alternatives
—
1. Introduction
Anabolic‑steroid compounds are synthetic derivatives of the male sex hormone testosterone.
They possess two main pharmacological actions:
Action Effect
Anabolism (muscle building) Increases protein synthesis in skeletal muscle, leading to hypertrophy.
Androgenic (male‑characteristic traits) Stimulates development of secondary sex characteristics
such as facial hair, deepening of the voice, and increased libido.
The dual nature of these hormones explains why they are used
both medically (e.g., treating hormone deficiencies, muscle wasting disorders) and illicitly for performance enhancement or body‑building purposes.
—
2. A Detailed Look at Testosterone
Testosterone is the most well‑known endogenous steroid hormone
that exerts significant anabolic and androgenic effects in men.
Category Details
Chemical Formula C₃₂H₄₀O₂
Molecular Weight 288.43 g/mol
Structure A cyclopentanoperhydrophenanthrene nucleus with a double bond between C4–C5, an aldehyde at C17α (in the enone form), and
a hydroxyl group at C3.
Sources Primarily produced by Leydig cells in testes; small amounts from adrenal cortex.
Metabolism Reduced to testosterone or oxidized to dihydrotestosterone via 5α-reductase.
Half-life (oral) ~2–4 hours (short due to rapid hepatic metabolism).
—
2. Synthesis of the Hormone (Testosterone) – General Route
Below is a concise outline of a common laboratory synthesis for testosterone starting from commercially available precursors.
2.1 Overview of Steps
Step Transformation Key Reagents & Conditions
A Conversion of cholesterol to Δ⁵-sterol (e.g., pregnenolone) Acidic or enzymatic cleavage; e.g.,
using cholesterol oxidase, followed by oxidation.
B Formation of the Δ⁴-pregnene core (pregnenolone →
progesterone) Oxidation with PCC or Swern conditions to introduce a ketone at C-20 and
eliminate C-3 hydroxyl.
C Reduction & epoxidation to form the A‑ring double bond
(progesterone → 5α‑dihydroprogesterone) Stereoselective reduction with NaBH₄, followed by epoxidation at C-4/5 with mCPBA.
D Opening of the epoxide and installation of C‑3 hydroxyl (via diol cleavage) Acidic hydrolysis to
yield a 3‑OH group while maintaining stereochemistry.
E Alkene isomerization & selective oxidation at C‑11 (to form 11‑hydroxy group) Sharpless epoxidation on the alkene, followed by oxidative cleavage with
KMnO₄ or OsO₄/H₂O₂ to yield a ketone/aldehyde at C‑11.
F Final reduction & dehydration steps to produce the unsaturated lactone ring (β‑unsaturation) Wittig olefination to
introduce double bond, then intramolecular esterification with
a base (NaH or LiHMDS) to close lactone ring and form conjugated system.
1.3 Detailed Stepwise Transformation
Below is an annotated, step-by-step transformation plan from the starting material \(S\)
to the target compound \(T\). Each entry includes reagents,
stoichiometry, reaction conditions, and rationale.
Step Transformation Reagents & Conditions Notes / Rationale
1 Protect phenol as methyl ether NaH (1.5 equiv), THF, rt
→ 60 °C, 2 h; then MeI (1.5 equiv) Avoids phenolic acidity that
could interfere with subsequent deprotonation
2 Deprotect methoxy group (if needed) BBr₃ (1.0 equiv) in DCM, –78 °C → rt,
12 h Regenerates free phenol for further functionalization
3 Synthesize α‑amino ester Standard coupling of amino acid
with H₂N‑CH₂CO₂H via carbodiimide chemistry (DCC/HOBt) Forms the
core skeleton for the peptide chain
4 Reduce nitro group to amine SnCl₂·2H₂O in ethanol,
reflux Converts aromatic nitro to amino, enabling further substitution
5‑7. Peptide coupling steps Use HATU/DIPEA in DMF;
N‑terminal protection with Boc or Fmoc; deprotection with TFA (Boc) or piperidine (Fmoc) Assemble the peptide sequence stepwise, controlling
stereochemistry
8. Final deprotection & purification Removal of side‑chain protecting groups (e.g., trifluoroacetic acid for tert‑butyl and tBu esters), reverse‑phase HPLC Isolate pure compound; confirm purity >99%
Key Reagents/Conditions:
Step Typical Reagent Conditions
Coupling HATU / DIC / EDCI + DIPEA 0 °C → rt, 1–3 h
Protection Boc anhydride (di-tert-butyl dicarbonate) 0 °C → rt, 2–4 h
Deprotection TFA in DCM (1:9 v/v) 30 min – 1 h
Reductive alkylation NaBH(OAc)₃ + aldehyde 0 °C → rt, 12–18 h
Saponification LiOH or NaOH in MeOH/H₂O rt, 2–4 h
—
5. Summary of the Synthetic Route
Protection – Boc‑protect the primary amine(s) to prevent side reactions.
Linker Assembly – Couple the protected amine with
a linker fragment (e.g., ethylene glycol spacer, PEG unit, or triazole from
click chemistry).
Target Attachment – Introduce the target ligand by coupling
an activated acid/anhydride or via click chemistry to yield the final conjugate.
Deprotection / Finalization – Remove protecting groups and perform any necessary purification (HPLC, chromatography) to obtain the pure functionalized
compound.
This general strategy accommodates a wide range of functional groups, ensuring
that the final molecule is compatible with downstream biological applications.
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