Bat Mallet Hammer

Bat Mallet Hammer

(25 customer reviews)

₹1,890.00

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Color

Wood Color

25 reviews for Bat Mallet Hammer

  1. Mauricio –

    Oxandrin Oxandrolone Dosing, Indications, Interactions, Adverse Effects, And More

    Comprehensive Overview of Clofarabine

    (a nucleoside analogue used primarily for acute lymphoblastic leukemia)

    —

    1. Indications

    Disease Typical regimen

    B‑cell Acute Lymphoblastic Leukemia (ALL) – children and adults  Intravenous infusion, 2–5 mg/m²/day
    × 3–5 days (depending on phase)

    T‑cell ALL  Same as above; often combined with chemotherapy backbone

    Other B‑cell malignancies (e.g., mantle cell lymphoma) – off‑label  Single‑agent or in combination

    —

    2. Dosage & Administration

    Adult Regimens

    Standard dose: 5 mg/m² IV over 1–2 h daily × 3 days.

    Induction phase (children): 5 mg/m² IV × 4 days per cycle; repeat cycles per
    protocol.

    Pediatric Dosing

    Age Dose (mg/m²)

    anavar and winstrol cycle dosage biliary excretion P-gp inhibitors or inducers not well studied Limited
    data; monitor for unexpected changes in efficacy/toxicity.

    —

    6. Summary

    Mechanism: The drug is a selective inhibitor of the intracellular calcium‑activated chloride
    channel TMEM16A (ANO1), reducing chloride secretion, inflammation, and intestinal motility.

    PK Profile: Oral bioavailability ~35 % with rapid absorption (Tmax ≈ 0.5–2 h).
    AUC increases linearly up to 200 mg; exposure at 400 mg is
    approximately double that at 200 mg.

    Drug‑Drug Interactions:

    – Not a substrate, inhibitor, or inducer of major CYP enzymes or P-gp.

    – Limited evidence for interactions with other anti‑inflammatory agents or NSAIDs
    beyond additive GI effects.

    Clinical Use: Effective in ulcerative colitis and irritable bowel syndrome–diarrhea; dosing generally starts at 50 mg twice daily, titrated up to 200 mg twice daily.
    Dose adjustment may be necessary for renal impairment but not
    for hepatic disease.

    These points provide a concise pharmacokinetic profile, interaction potential, and therapeutic guidance for the drug.

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